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Settembre 9, 2023

Gastric-Type Adenocarcinoma of the Uterine Cervix: Role of Magnetic Resonance Imaging for Diagnosis and Management

Gastric-type adenocarcinoma of the uterine cervix is an aggressive, human papillomavirus-independent subtype carrying poor prognosis, with greater propensity for metastases, and resistance to chemotherapy and radiotherapy. Distinctive MRI features of intratumoral cysts, upper endocervical location with endophytic growth, and heterogeneous enhancement which can aid in identification of GAS and differentiation from cervical squamous cell carcinoma and other benign cervical multicystic lesions. Targeted and adequate biopsy on suspicious solid areas identified on MRI is crucial for early definitive histological diagnosis. High soft-tissue resolution of MRI and the use of dedicated double-oblique imaging planes allows accurate local tumour staging. Diffusion-weighted imaging and enhancement pattern make MRI indispensable in differentiating between post-irradiation fibrosis and recurrent tumour on post-treatment follow-up.
Settembre 9, 2023

Genitourinary fluoroscopic contrast examinations: what role do they have today?

1. Working group SIRM-SIAARTI-SNR-AINR coordinator Tamburrini O. I mezzi di contrasto in diagnostica per immagini, raccomandazioni all’uso, reazioni avverse e trattamento, Omicron Editrice Genova. 2. R Ruiz-Cruces 1, F Ruiz, M Pérez-Martínez, J López, I Tort Ausina, A D de los Ríos; Patient dose from barium procedures, Br J Radiol . 2000 Jul;73(871):752-61. doi: 10.1259/bjr.73.871.11089468. 3. Disantis DJ, Lewis JI, Menias CO, Balfe DM, Morgan DE, Cernigliaro JG. Imaging tips for performing a perfect barium swallow. Radiographics. 2019 Sep-Oct;39(5):1325-6. 4. A. L. F. Yasin, O. Aljaziri, A. H. M. Sha'ban, A. Yousaf, F. S. R. Ameerudeen Moulana, M. A. H. Shah; A radiologist’s guide to the role of urethrography in the assessment of urethral diseases in adult males, DOI 10.26044/ecr2021/C-10954 https://epos.myesr.org/poster/esr/ecr2021/C-10954/findingsandproceduredetails 5. Catalá V et al: CT findings in urinary diversion after radical cystectomy: postsurgical anatomy and complications. Radiographics. 29(2):461-76, 2009 6. Hysterosalpingography: a reemerging study. Simpson WL Jr, Beitia LG, Mester J. Radiographics. 2006 Mar-Apr;26(2):419-31. 7. Chalazonitis, A., Tzovara, I., Laspas, F., Porfyridis, P., Ptohis, N., & Tsimitselis, G. (2009). Hysterosalpingography: technique and applications. Current Problems in Diagnostic Radiology, 38(5), 199–205. https://doi.org/10.1067/j.cpradiol.2008.02.003
Settembre 9, 2023

Gynecological Masses: Tips for Determining their Site of Origin

The identification of the origin and nature of gynecological pelvic masses can be challenging. The most common origin of lesions of the upper female reproductive tract lesions is the ovaries. Radiological clues to identify an ovarian origin are the Phantom Ovary Sign, the Ovarian Vascular Pedicle Sign, the Beak Sign, the Ovarian Crescent Sign, and the Posterior Displacement of extraperitoneal structures. In cases where an ovarian origin is ruled out, attention is directed to consider a fallopian tube origin. The characteristic morphological signs are the Cogwheel Sign, the Waist Sign, and the "C" or "S" shaped configuration. Furthermore, the possibility of a uterine origin can be suspected by the Claw Sign and the Bridging Vessel Sign. There are also pelvic gynecological masses with origin in the broad ligament, vagina, and cervix. Concluding, radiological features, along with clinical information, aid in narrowing the differential diagnosis.
Settembre 9, 2023

Gynecological surgery’s complication: a radiological anatomical based approach to the diagnosis

Gynecological surgery is not free from complications and their correct diagnosis is essential for patient management.Compartmentalization of the pelvic anatomy can assist the radiologist in identifying the correct post surgical complications.
Settembre 10, 2023

High density flexible coil arrays for improved SNR in prostate MRI

High density receiver coil arrays allowed by AIR coil technology can provide improved SNR in prostate MRI.
Settembre 9, 2023

High intensity focused ultrasound (HIFU) in the treatment of cancer of the prostate – Our experience

BIBLIOGRAPHY 1. Salgaonkar VA, Prakash P, Rieke V, et al. Model-based feasibility assessment and evaluation of prostate hyperthermia with a commercial MR-guided endorectal HIFU ablation array.Med Phys. 2014;41(3):033301. doi:10.1118/1.4866226) 2. ChaussyCG: Ultrasonidos de alta intensidad focalizados(HIFU) para el tratamiento local del cancerde prostata: papel actual. Archivos Españoles de Urología, 2011; 64: 493–96 NCCN Guidelines® -Prostate Cancer Version 4.2022 3. ChaussyC, ThueroffS: Complete remission in metastatic prostate cancer after combined local and systemic therapy. Urology, 2006; 68: 197–98 4. Vyacheslav S, Leonid S, Mikhail V, Ravil K: High-Intensity Focused Ultrasound (HIFU) For the Prostate Cancer: 5-year Experience. International Journal of Tumor Therapy, 2012; 1: 20–25 5. Muller BG, FüttererJJ, Gupta RT, et al. The role of magnetic resonance imaging (MRI) in focal therapy for prostate cancer: recommendations from a consensus panel.BJU Int. 2014;113(2):218-227. doi:10.1111/bju.12243 6. Poissonnier L, Chapelon JY, Rouviere O et al: Control of prostate cancer by transrectal HIFU in 227 patients. Eur Urol, 2007;51: 381–87 7. BlanaA, Walter B, RogenhoferS et al: High-intensity focused ultrasound for the treatment of localized prostate cancer: 5-year experience. Urology, 2004; 63: 297–300 8. Uchida T, OhkusaH, Yamashita H et al: Five years experience of transrectal high-intensity focused ultrasound using the sonablatedevice in the treatment of localized prostate cancer. Int J Urol, 2006; 13: 228–33
Settembre 9, 2023

How embryology knowledge can help radiologists in the differential diagnosis of Wolffian duct (WD) related pathology

The mesonephric duct, also known as Wolffian duct (WD), is a paired organ that during embryonic development forms as a part of urogenital system draining the primitive kidney (mesonephros) into the cloaca and giving off lateral branch forming the ureteric bud. In both male and female, WD develops into urinary bladder trigone and ureters.  In male, it has a fundamental role in reproductive organ’s formation (epididymis, ejaculatory duct, vas deferens, and seminal vesicle). In female, WDs degenerate, although inclusions cyst (e.g., Gardner’s cyst) or remnant may persist.     It is well known that WD anomalies are usually diagnosed in paediatric patient, but Radiologists can encounter these anomalies also in adult population. Due to close relationship between urinary and reproductive system development, congenital malformation (especially renal agenesia / malformation) is often associated to each other.  The aim of our work is to review embryology, anatomy and pathologies related to WD through a multi modal approach (Ultrasound US, Computed Tomography CT and Magnetic Resonance imaging MRI) to make Radiologists more familiar of such conditions and their associations and to guarantee a correct diagnosis not only in paediatric patients but also in the adult population. 
Settembre 9, 2023

How to differentiate endometrial polyps from endometrial carcinomas on MRI: Tips and tricks

1. Chaudhry S, Reinhold C, Guermazi A, Khalili I, Maheshwari S. Benign and malignant diseases of the endometrium. Top Magn Reson Imaging. 2003 Aug;14(4):339-57. 2. Brenner PF. Differential diagnosis of AUB. Am J Obstet Gynecol. 1996;175:766-9. 3. Salim S, Won H, Nesbitt-Hawes E, Campbell N, Abbott J. Diagnosis and management of endometrial polyps: a critical review of the literature. J Minim Invasive Gynecol. 2011 Sep-Oct;18(5):569-81. 4. Kurman RJ, Zaino RJ, Norris HJ (1994) Endometrial carcinoma. In: Kurman RJ (ed) Blaustein’s pathology of the female genital tract, 4th edn. Springer, Berlin Heidelberg New York, pp 439–486. 5. Reslová T, Tosner J, Resl M, Kugler R, Vávrová I. Endometrial polyps. A clinical study of 245 cases. Arch Gynecol Obstet. 1999;262(3-4):133-9. 6. Peterson WP and Novak ER. Endometrial polyps. Obstet Gynecol 1956 Jul;8(1):40-9. 7. Weschler T. Taking charge of your fertility. Revised ed. New York: Harper Collins, 2002. 8. Hamani Y, Eldar I, Sela HY, Voss E, Haimov-Kochman R. The clinical significance of small endometrial polyps. Eur J Obstet Gynecol Reprod Biol. 2013 Oct;170(2):497-500. 9. Grasel RP, Outwater EK, Siegelman ES, Capuzzi D, Parker L, Hussain SM. Endometrial polyps: MR imaging features and distinction from endometrial carcinoma. Radiology. 2000 Jan;214(1):47-52. 10. Takeuchi M, Matsuzaki K, Uehara H, Yoshida S, Nishitani H, Shimazu H. Pathologies of the uterine endometrial cavity: usual and unusual manifestations and pitfalls on magnetic resonance imaging. Eur Radiol. 2005 Nov;15(11):2244-55. 11. Park BK, Kim B, Park JM, Ryu JA, Kim MS, Bae DS, Ahn GH. Differentiation of the various lesions causing an abnormality of the endometrial cavity using MR imaging: emphasis on enhancement patterns on dynamic studies and late contrast-enhanced T1-weighted images. Eur Radiol. 2006 Jul;16(7):1591-8. 12. Fujii S, Matsusue E, Kigawa J, Sato S, Kanasaki Y, Nakanishi J, Sugihara S, Kaminou T, Terakawa N, Ogawa T. Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results. Eur Radiol. 2008 Feb;18(2):384-9. 13. Wang J, Yu T, Bai R, et al. The value of the apparent diffusion coefficient in differentiating stage IA endometrial carcinoma from normal endometrium and benign diseases of the endometrium: initial study at 3-T magnetic resonance scanner. Journal of Computer Assisted Tomography. 2010 May-Jun;34(3):332-337. 14. Sala E, Rockall AG, Freeman SJ, Mitchell DG, Reinhold C. The added role of MR imaging in treatment stratification of patients with gynecologic malignancies: what the radiologist needs to know. Radiology. 2013 Mar;266(3):717-40. 15.Pintican R, Bura V, Zerunian M, Smith J, Addley H, Freeman S, Caruso D, Laghi A, Sala E, Jimenez-Linan M. MRI of the endometrium - from normal appearances to rare pathology. Br J Radiol. 2021 Sep 1;94(1125):20201347. 16. Sironi S, Colombo E, Villa G, Taccagni G, Belloni C, Garancini P, DelMaschio A. Myometrial invasion by endometrial carcinoma: assessment with plain and gadolinium-enhanced MR imaging. Radiology. 1992 Oct;185(1):207-12. 17. Lien HH, Blomlie V, Tropé C, Kaern J, Abeler VM. Cancer of the endometrium: value of MR imaging in determining depth of invasion into the myometrium. AJR Am J Roentgenol. 1991 Dec;157(6):1221-3. 18. Imaoka I, Sugimura K, Masui T, Takehara Y, Ichijo K, Naito M. Abnormal uterine cavity: differential diagnosis with MR imaging. Magn Reson Imaging. 1999 Dec;17(10):1445-55. 19. Yamashita Y, Harada M, Sawada T, Takahashi M, Miyazaki K, Okamura H. Normal uterus and FIGO stage I endometrial carcinoma: dynamic gadolinium-enhanced MR imaging. Radiology. 1993 Feb;186(2):495-501. 20. Joja I, Asakawa M, Asakawa T, Nakagawa T, Kanazawa S, Kuroda M, Togami I, Hiraki Y, Akamatsu N, Kudo T. Endometrial carcinoma: dynamic MRI with turbo-FLASH technique. J Comput Assist Tomogr. 1996 Nov-Dec;20(6):878-87. 21. Tanaka YO, Nishida M, Tsunoda H, Ichikawa Y, Saida Y, Itai Y. A thickened or indistinct junctional zone on T2-weighted MR images in patients with endometrial carcinoma: pathologic consideration based on microcirculation. Eur Radiol. 2003 Aug;13(8):2038-45.
Settembre 9, 2023

Image guided thermal ablation of T1 renal cell cancer: A single centre experience.

Title: Image guided thermal ablation of T1 renal cell cancer: A single centre experience. Purpose: To evaluate the oncological outcomes and survival times after ablation of T1 renal cell carcinoma (RCC) in our unit over a 9-year period. Materials and Methods: We retrospectively reviewed all patients with biopsy proven RCC who underwent image guided tumour ablation (IGTA) of a T1 tumour between 1st March 2013 and 1st August 2022. Data collected included: patient demographics, tumour size and histology, pre and post procedure creatinine, ablation technique, complications, oncological outcomes, disease free survival and overall survival. Results: 50 ablative procedures were performed on 46 RCC (mean tumour size 2.6cm) in 45 patients. Technical success was achieved in 100% of tumours (n=46/46). Complications occurred in 8% of procedures (n=4/50). Median clinical follow-up was 23 months (range 3 - 88). There was no significant change in creatinine due to IGTA. Primary efficacy of ablation was 94% (43/46 tumours). Microwave ablation (MVA) was less likely to achieve local tumour control when compared to radiofrequency ablation (RFA) (82% (14/17) vs 100% (28/28) respectively, (p=0.02). Larger median RCC diameter was associated with failed primary efficacy in the MWA group (3.8 cm vs 2.4 cm respectively, p= 0.045). Overall survival rates at 1, 3 and 5 years was 97.4% , 80% and 50% respectively. Conclusion: IGTA is a highly efficacious modality and provides an effective durable treatment option for patients with T1 RCCs. Primary efficacy was greater with RFA than MWA. Primary efficacy failure in the MWA group is associated with greater median RCC size.