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Nijssen, E. C., Rennenberg, R. J., Nelemans, P. J., Essers, B. A., Janssen, M. M., Vermeeren, M. A., Ommen, V. V., & Wildberger, J. E. (2017). Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial. Lancet (London, England), 389(10076), 1312–1322. https://doi.org/10.1016/S0140-6736(17)30057-0 Sebastià, C., Páez-Carpio, A., Guillen, E., Paño, B., Garcia-Cinca, D., Poch, E., Oleaga, L., & Nicolau, C. (2021). Oral hydration compared to intravenous hydration in the prevention of post-contrast acute kidney injury in patients with chronic kidney disease stage IIIb: A phase III non-inferiority study (NICIR study). European journal of radiology, 136, 109509. https://doi.org/10.1016/j.ejrad.2020.109509 Newhouse, J. H., Kho, D., Rao, Q. A., & Starren, J. (2008). Frequency of serum creatinine changes in the absence of iodinated contrast material: implications for studies of contrast nephrotoxicity. AJR. American journal of roentgenology, 191(2), 376–382. https://doi.org/10.2214/AJR.07.3280

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This internal audit shows a good accuracy of prostate MRI at our centre.

1. MRI radiomics warrants consideration as a possible solution to address the constraints of MRI in local staging of PCa. 2. The 13 included studies showed an overall AUC of 0.80 for EPE prediction of PCa, with high heterogeneity (84.7%, p < .001), methodological issues and poor clinically orientation. 3. Methodologically robust radiomics research is needed to bring added value to clinical nomograms at patient level.

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Seventeen patients with locally advanced cancer (LACC) undergoing brachytherapy (BRT) after external beam radiotherapy (EBRT) were recruited. MR images were analysed, considering volume and ADC as variables during treatment. A significant decrease in volume during treatment was observed, more pronounced after EBRT than after BRT, which serves as a boost. Conversely, the ADC value appeared to increase somehow linearly with treatment, with mean initial values of 0.71 ± 0.06 × 10−3 mm2/s and final values of 1,29 ± 0.50 × 10−3 mm2/s. In relapsing patients, the difference between initial and post-treatment ADC values seemed significantly smaller compared to responder patients.

MRI is fundamental in the diagnosis and staging of the prostate cancer. EPE score is a valid strategy to detect extra-capsular extension of the tumor. Our classification, combining EPE score together with “capsular enhancement sign” enhances the clinical accuracy in reporting the locoregional staging.

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